Feeling so uncomfortable around other people, one 55-year-old accountant routinely waited until 3 a.m. to take out the garbage to avoid running into neighbors. At work, the social interactions were so painful that he quit.

T he ads seem to be everywhere - on television, in magazines, doctors' offices, the Internet: Are you feeling tense? Having difficulty sleeping? Scared of criticism?

If so, they suggest, the answer could be a pill - an antidepressant, to be exact.

The drugs that revolutionized the treatment of depression a decade ago now are increasingly used to treat anxiety disorders, mental illnesses that can cause paralyzing worry or intense fear of social situations. Caused by a deficiency in brain chemistry, the disorders can indeed be remedied by potent mood-altering medications such as Paxil and Effexor.

Drug companies commonly seek new uses for their drugs; it's a way of expanding their market and getting a greater return on the money spent doing research. But now it appears they could be capturing a new segment of patients - those with less serious disorders, such as occasional anxiety.

Since the federal government approved the drugs for generalized anxiety disorder and social phobia, prescriptions for the medications have soared. Doctors and other health experts, meanwhile, report a marked increase in the number of patients with anxiety disorders who are

seeking relief.

Just about everyone has experienced situational anxieties - when personal or professional stress keeps us keyed up and disturbs our sleep - and it can be difficult to pinpoint exactly when life's mundane worries escalate into a full-blown psychiatric disorder. "There are few conditions where there's a black-and-white cutoff," said Dr. Franklin Schneier, a psychiatrist at Columbia University in New York.

Consequently, some mental health experts say, people with normal angst may get powerful medications they don't need, sometimes suffering from side effects such as agitation, insomnia, loss of libido and - when they try to quit the drugs - withdrawal. At a time when managed-care companies are cutting expenses, this marketing of the drugs also increases consumer demand for costly name brands when generics, or even counseling, may do the job just as well.

The advertising is "a double-edged sword," said Dr. Michael Brase, medical director for behavioral services for WellPoint Health Networks Inc., the parent of Blue Cross of California. "It's helped some people realize they need to be on medication, but others may be just going though a bad patch in their lives. And that's what muddies the waters."

GlaxoSmithKline, the maker of Paxil, says the advertising campaigns de-stigmatize anxiety disorders in the same way that publicity surrounding the introduction of Prozac brought depression out of the closet 15 years ago. "Our intention is to educate the public about the symptoms of these disorders" so that people with serious mental illnesses will seek treatment, said Dr. Philip Perera, a psychiatrist and group director for clinical psychiatric research at GlaxoSmithKline in Philadelphia.

But it's the publicity that has caused many mental health experts to suspect that people are getting medications for mental disorders that were once believed to be relatively rare.

For example, after Paxil was approved to treat social phobia in 1999, the company nearly tripled its advertising spending, from $31.5 million in 1999 to $91.7 million in 2000. In April 2001, the FDA approved the drug for generalized anxiety disorder as well. In the first six months of 2002, advertising for the drug topped the $60 million mark, according to figures compiled by CMR, a market research company.

Prescriptions are rising accordingly. Last year, 26 million prescriptions for Paxil were dispensed. This year, more than 16.9 million prescriptions were filled in the first half of the year, a projected spike of more than 25 percent.

"Advertising definitely induces demand for these products," said Steven Findlay, director of research for the National Institute for Health Care Management, a Washington, D.C., non-profit agency. "But we don't know what percentage of these prescriptions are being written inappropriately."

One out of every five people will suffer from an anxiety disorder at some time, according to Ronald Kessler, a researcher at Harvard Medical School in Boston. Such disorders include obsessive- compulsive disorder, panic attacks, post-traumatic stress syndrome and the two most common - social phobia and generalized anxiety.

Generalized anxiety disorder afflicts about 4 percent of the population, the 10 million people who are paralyzed by irrational fears. Unlike people who are socially phobic, they don't fear human contact; they fret constantly about everything.

"They're like 'worry machines,' " said Jerilyn Ross, president of the Anxiety Disorders Association of America in Silver Spring, Md. "They can't eat, they can't sleep, they're irritable and jumpy, and you can't calm them down with facts."

Similarly, anywhere from 3 percent to 13 percent of the population is crippled by social phobia, or social anxiety disorder, in which people are filled with intense dread and avoid everyday social situations. Social phobics fear public humiliation or being judged by others, and may turn down a promotion, quit their jobs, or avoid leaving the house rather than deal with people. But the line between generalized anxiety disorder and normal fears is not as clear as it may seem. Almost half of all Americans - 40 percent to 45 percent, according to recent polls - consider themselves shy, which is not a psychological disorder. Here again, it's tricky determining when shyness is debilitating enough to require pharmaceutical interventions.

"It's to the advantage of the drug companies to blur that line," said Bernardo J. Carducci, a professor of psychology and director of the Shyness Research Institute at Indiana University in New Albany. "All of a sudden, that gives them a tremendous market."

Family physicians dispense about 60 percent of the prescriptions for anti-depressants, but they spend an average of only seven minutes with a patient, so there often isn't enough time to do an adequate psychological assessment, Brase said. Consequently, when patients insist they want a particular drug, doctors often cave in, rather than reviewing other therapeutic options.

"Patients come in with a perception that this medication is going to work for them, and if physicians take the time to challenge that assumption, there's often a credibility issue - almost like the patients don't believe them," said Martin Fornataro, the West Coast director of pharmacy for Cigna HealthCare in Glendale, Calif. "So physicians end up capitulating to their demands."

On the other hand, some doctors must spend so much time clarifying whether a drug is warranted that the discussions can "crowd out more important things that need to be discussed," said Dr. Les Zendle, associate medical director for Kaiser Permanente Southern California in Pasadena.

This Article has been submitted by the Jeremy's Prophecy Dot Com team for informational and educational purposes. Jeremy's Prophecy Dot Com is a website dedicated to telling the story of Jeremy Jacobs, a character in the novel, Jeremy's Prophecy Dot Com.